TCR² Therapeutics Presents Preclinical Data on Functional Activity of Gavo-cel at the Society for Immunotherapy of Cancer
Mesothelin (MSLN), a protein which plays an active role in both malignant transformation and tumor aggressiveness, undergoes shedding in the tumor microenvironment, generating soluble mesothelin (sMSLN). These sMSLN levels are associated with tumor burden in malignant pleural/peritoneal mesothelioma (MPM). High, circulating levels of sMSLN have been implicated as a potential obstacle to maximizing the activity of anti-mesothelin therapies. To address the potential impact of sMSLN on the function of gavo-cel, acute and chronic in vitro challenge studies were performed in the presence of supraphysiological sMSLN levels. Levels of sMSLN 50-fold higher than were measured in MPM patients had no observed impact on the functional activity of gavo-cel T cells with respect to tumor cell killing and cytokine production. These results suggest that the levels of sMSLN present in the circulation of MPM patients likely do not pose a concern for the clinical activity of gavo-cel.
Poster Title: The Functional Activity of gavo-cel TRuC-T Cells is Not Impaired by Soluble Mesothelin
Abstract Number: 219
Date & Time:
The poster presented at SITC is available in the Presentations section of the Investors page of the Company’s website at investors.tcr2.com.
About TCR2 Therapeutics
TCR2 Therapeutics Inc. is a clinical-stage cell therapy company developing a pipeline of novel T cell therapies for patients suffering from solid tumors. The Company is focused on the discovery and development of product candidates against novel and complex targets utilizing its proprietary T cell receptor (TCR) Fusion Construct T cells (TRuC®-T cells). The TRuC platform is designed to specifically recognize and kill cancer cells by harnessing signaling from the entire TCR, independent of human leukocyte antigens (HLA). For more information about TCR2, please visit www.tcr2.com.
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Source: TCR2 Therapeutics